Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 7/20 | 0.37 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072378 | 0.72 | CHRNA4 (0.49) | ALDH1A1KMT2A | |
| SCHEMBL7068654 | 0.68 | POLB (0.40) | MAPTALDH1A1 | |
| SCHEMBL11483350 | 0.67 | EPAS1 (0.53) | ALDH1A1ACLYEPAS1STK39 | |
| SCHEMBL3060862 | 0.67 | — | — | |
| SCHEMBL5657660 | 0.66 | ALDH1A1 (0.42) | MAPTALDH1A1NPSR1KMT2ACARM1 | |
| SCHEMBL3061025 | 0.66 | ALDH1A1 (0.68) | MAPTALDH1A1STK39NPSR1CARM1 | |
| SCHEMBL3325853 | 0.65 | — | — | |
| SCHEMBL11098348 | 0.65 | KMT2A (0.41) | MAPTALDH1A1ACLYKMT2A | |
| SCHEMBL3972807 | 0.63 | CTNNB1 (0.54) | MAPTKMT2A | |
| SCHEMBL14280735 | 0.63 | HTT (0.53) | MAPTALDH1A1EPAS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000649-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |