Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SELL | P14151 | 1/20 | 0.46 |
| ▸ | SELP | P16109 | 1/20 | 0.46 |
| ▸ | SELE | P16581 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TPMT | P51580 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090180 | 1.00 | PTPN1 (0.53) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL68928 | 0.87 | TDP1 (0.67) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL129762 | 0.82 | ACHE (0.57) | PTPN1TDP1MAPTALDH1A1KMT2A | |
| SCHEMBL8084791 | 0.81 | TDP1 (0.52) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL1427958 | 0.79 | ACHE (0.70) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL10106591 | 0.79 | PTPN1 (0.62) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL29421877 | 0.79 | PTPN1 (0.62) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL29421895 | 0.79 | ACHE (0.70) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL18838191 | 0.78 | PIM1 (0.45) | PTPN1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL4490735 | 0.78 | TDP1 (0.54) | PTPN1TDP1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019136112-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-07-11 | — | — | WO | disclosed |
| US-10308579-B2 | Method of bisphenol manufacture | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-06-04 | — | — | US | disclosed |
| EP-3386938-A1 | METHOD OF BISPHENOL MANUFACTURE | SABIC Global Technologies B.V. (NL) | 2018-10-17 | — | — | EP | disclosed |
| US-20180265441-A1 | METHOD OF BISPHENOL MANUFACTURE | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2018-09-20 | — | — | US | disclosed |
| EP-3202765-A1 | POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR | Xuanzhu Pharma Co., Ltd. (CN) | 2017-08-09 | — | — | EP | disclosed |
| WO-2017100164-A1 | METHOD OF BISPHENOL MANUFACTURE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-15 | — | — | WO | disclosed |
| US-8957069-B2 | Benzofuran derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-17 | — | — | US | disclosed |
| EP-2781513-A1 | Benzofuran derivatives | Takeda Pharmaceutical Company Limited (JP) | 2014-09-24 | — | — | EP | disclosed |
| EP-2406243-B1 | BENZOFURAN DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2014-05-07 | — | — | EP | disclosed |
| US-8288390-B2 | Benzofuran derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20120046277-A1 | BENZOFURAN DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-23 | — | — | US | disclosed |
| EP-2406243-A1 | BENZOFURAN DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20100234357-A1 | Benzofuran derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-16 | — | — | US | disclosed |
| WO-2010104194-A1 | BENZOFURAN DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-16 | — | — | WO | disclosed |
| US-4656310-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4532355-A | Substituted triaryl phosphonium derivatives | HOFFMANN-LA ROCHE INC. (US) | 1985-07-30 | — | — | US | disclosed |
| US-4319048-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-03-09 | — | — | US | disclosed |
| US-4224244-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4215215-A | 9-Phenyl-nonate traene compounds | HOFFMANN-LA ROCHE INC. (US) | 1980-07-29 | — | — | US | disclosed |
| US-4105681-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265441-A1 | METHOD OF BISPHENOL MANUFACTURE | PBRM1, ELL, HPD | PTPN1 4242/4885TDP1 4381/4885MAPT 1485/4885 |
| US-10308579-B2 | Method of bisphenol manufacture | PBRM1, ELL, HPD | PTPN1 4242/4885TDP1 4381/4885MAPT 1485/4885 |
| US-20100234357-A1 | Benzofuran derivatives | AHR, BRPF3, CBR3 | PTPN1 3602/4885TDP1 4771/4885MAPT 3969/4885 |
| US-20120046277-A1 | BENZOFURAN DERIVATIVES | BRPF3, BRD1, CBR3 | PTPN1 4030/4885TDP1 4781/4885MAPT 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.