Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641853 | 0.83 | TSHR (0.41) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT | |
| SCHEMBL7603497 | 0.79 | CA2 (0.45) | CA2TSHRSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL7392580 | 0.76 | TSHR (0.40) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT | |
| SCHEMBL1534226 | 0.71 | ALDH1A1 (0.48) | CA2TSHRALDH1A1HTT | |
| SCHEMBL6962624 | 0.71 | TSHR (0.41) | CA2TSHRSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL4471027 | 0.71 | TDP1 (0.41) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT | |
| SCHEMBL27676059 | 0.71 | TDP1 (0.45) | CA2TSHRSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL14509415 | 0.71 | APEX1 (0.39) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT | |
| SCHEMBL11741640 | 0.71 | TSHR (0.50) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT | |
| SCHEMBL1584530 | 0.70 | TSHR (0.48) | TSHRSMN1; SMN2TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |