Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580627 | 0.90 | NCF1 (0.41) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6580761 | 0.83 | MAPT (0.42) | ALDH1A1PDE10APPARGLMNA | |
| SCHEMBL6580770 | 0.83 | NCF1 (0.40) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6578833 | 0.83 | NCF1 (0.40) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6578390 | 0.80 | NQO1 (0.41) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6578780 | 0.78 | NCF1 (0.40) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6581519 | 0.78 | MCHR1 (0.50) | ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL6578484 | 0.78 | NCF1 (0.39) | NCF1ALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL6578371 | 0.75 | ALDH1A1 (0.44) | ALDH1A1PDE10ALMNAPOLBTUBB4A | |
| SCHEMBL6581464 | 0.74 | KDM4E (0.44) | NCF1ALDH1A1CASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |