Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580627 | 0.87 | NCF1 (0.41) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6936592 | 0.87 | KDM4E (0.42) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6578484 | 0.85 | NCF1 (0.39) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6576073 | 0.82 | KDM4E (0.38) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6576127 | 0.82 | S1PR4 (0.42) | LMNAPOLBALDH1A1CYP2D6KLKB1 | |
| SCHEMBL6578833 | 0.82 | NCF1 (0.40) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6581525 | 0.78 | NCF1 (0.39) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6580770 | 0.77 | NCF1 (0.40) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6581464 | 0.77 | KDM4E (0.44) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL6581350 | 0.77 | BDKRB2 (0.37) | KDM4ELMNAALDH1A1KLKB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |