SCHEMBL6581771

SCHEMBL6581771

CS(=O)(=O)c1ccc(-c2cccc(C(O)O)c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.51
CTSK P43235 1/20 0.51
PTGS2 P35354 10/20 0.48
CA2 P00918 3/20 0.44
CA9 Q16790 3/20 0.44
CA12 O43570 2/20 0.44
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
RXRG P48443 1/20 0.44
CA1 P00915 2/20 0.43
KIF11 P52732 1/20 0.43
PTGS1 P23219 2/20 0.43
RORC P51449 2/20 0.42
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25094075 0.85 RXRA (0.57) CTSSCTSKPTGS2CA2CA9
SCHEMBL6586101 0.82 ENPP2 (0.50) PTGS2CA2CA9CA12CA1
SCHEMBL8770634 0.78 PTGS2 (0.68) PTGS2CA2CA9CA12CA1
SCHEMBL21296960 0.77 HSD17B1 (0.63) PTGS2CA2CA9CA12
SCHEMBL2844489 0.76 HDAC4 (0.54) CTSSCTSKPTGS2
SCHEMBL15771709 0.76 PTGS2 (0.50) CTSSCTSKPTGS2CA2CA9
SCHEMBL4191595 0.76 RXRA (0.47) RXRARXRBRXRG
SCHEMBL25490780 0.75 PTGS2 (0.53) PTGS2CA2CA9CA12CA1
SCHEMBL8646859 0.74 PTGS2 (0.68) PTGS2CA2CA9CA12CA1
SCHEMBL22973430 0.74 PTGS2 (0.52) PTGS2CA2CA9CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1406609-A2 SUBSTITUTED ARYL COMPOUNDS AS NOVEL CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2004-04-14 EP claimed
EP-1406609-A4 SUBSTITUTED ARYL COMPOUNDS AS NOVEL CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2004-04-14 EP claimed
WO-2002060378-A2 SUBSTITUTED ARYL COMPOUNDS AS CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2002-08-08 WO claimed
EP-1406609-A4 SUBSTITUTED ARYL COMPOUNDS AS NOVEL CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2004-04-14 EP disclosed
EP-1406609-A2 SUBSTITUTED ARYL COMPOUNDS AS NOVEL CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2004-04-14 EP disclosed
WO-2002060378-A2 SUBSTITUTED ARYL COMPOUNDS AS CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2002-08-08 WO disclosed