Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433659 | 1.00 | SLC6A1 (0.41) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL5680950 | 0.95 | SLC6A1 (0.38) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL660990 | 0.94 | SLC6A1 (0.44) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL5114077 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL165540 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL24912524 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL14772 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL22540086 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL14620877 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL1037842 | 0.88 | ALDH1A1 (0.47) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434774-A1 | 3-(4-SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003031438-A1 | 3-[4-(SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE]-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2003-04-17 | — | — | WO | disclosed |