Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.63 |
| ▸ | HTR1A | P08908 | 9/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739641 | 0.89 | ALDH1A1 (0.70) | ALDH1A1ADRA1BHTR1ASLC6A2SLC6A4 | |
| SCHEMBL6577757 | 0.87 | ALDH1A1 (0.73) | ALDH1A1ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL6583113 | 0.84 | ALDH1A1 (1.00) | ALDH1A1ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL10367403 | 0.84 | ADRA1B (0.63) | ALDH1A1ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL9347278 | 0.81 | KDM4E (0.62) | ALDH1A1ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL7410473 | 0.81 | ALDH1A1 (0.68) | ALDH1A1ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL11214631 | 0.79 | ADRA1B (0.61) | ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL3210355 | 0.78 | SLC6A2 (0.58) | ALDH1A1HTR1ASLC6A2SLC6A4CYP3A4 | |
| SCHEMBL6580326 | 0.78 | ADRA1B (0.72) | ADRA1BHTR1AADRA1AADRA1D | |
| SCHEMBL6577748 | 0.78 | ADRA1B (1.00) | ADRA1BHTR1AADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |
| EP-1200406-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005765-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-01-25 | — | — | WO | disclosed |