Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.46 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505328 | 0.84 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL9443940 | 0.81 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL1532826 | 0.81 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8982918 | 0.81 | RAB9A (0.57) | RAB9ASMN1; SMN2HPGDSLC6A4MAPT | |
| SCHEMBL17658995 | 0.81 | ALOX5 (0.58) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL5727839 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL632895 | 0.79 | MRGPRX4 (0.57) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12260990 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL1615947 | 0.79 | FFAR4 (0.56) | SMN1; SMN2MRGPRX4RXRARXRBMAPT | |
| SCHEMBL410222 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11944687-B2 | Carbohydrate conjugate RNA agents and process for their preparation | ALNYLAM PHARMACEUTICALS, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| EP-4253395-A2 | PROCESSES FOR THE PREPARATION OF CARBOHYDRATE CONJUGATED RNA AGENTS | Alnylam Pharmaceuticals, Inc. (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-2879718-B1 | PROCESSES FOR THE PREPARATION OF CARBOHYDRATE CONJUGATED RNA AGENTS | ALNYLAM PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-20190134206-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | ALNYLAM PHARMACEUTICALS, INC. | 2019-05-09 | — | — | US | disclosed |
| US-10086081-B2 | Carbohydrate conjugated RNA agents and process for their preparation | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-10-02 | — | — | US | disclosed |
| US-20150196655-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | BANK OF AMERICA, N.A. | 2015-07-16 | — | — | US | disclosed |
| EP-2879718-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | Alnylam Pharmaceuticals, Inc. (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014025805-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2014-02-13 | — | — | WO | disclosed |
| CN-101333196-B | 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors | STERIX LTD | 2012-06-27 | — | — | CN | disclosed |
| CN-100473648-C | Sulfamate-containing 1,2, 4-triazole derivatives as aromatase inhibitors | STERIX LTD (GB) | 2009-04-01 | — | — | CN | disclosed |
| EP-0014566-B1 | HALOGENATED BETA-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION | ELI LILLY AND COMPANY (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4357275-A | Novel oxazolinoazetidinones and process therefor | ELI LILLY AND COMPANY (US) | 1982-11-02 | — | — | US | disclosed |
| US-4271305-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| EP-0022628-A1 | Process for the preparation of oxazolinoazetidinones | ELI LILLY AND COMPANY (US) | 1981-01-21 | — | — | EP | disclosed |
| US-4243588-A | CYCLIZING A 2-CHLOROAZETIDINONE WITH LEAD FLUORIDE IN DIMETHYL SULFOXIDE TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4226986-A | 7-ACYLAMINO-3-HYDROXY-3-CEPHEM COMPOUND, TRIARYL PHOSPHITE DIHALIDE | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4105668-A | 6-AMINO-2,2-DIMETHYL-3-(1 -SUBSTITUTED TETRAZOL-5-YL)PENAM COMPOUND REACTED WITH HYDROGEN FLUORIDE | PFIZER INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4090027-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-05-16 | — | — | US | disclosed |
| US-4077978-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-3996374-A | Isoindole derivatives as appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10086081-B2 | Carbohydrate conjugated RNA agents and process for their preparation | RNASE1, IGF2BP1, IGF2BP2 | NPC1 745/4885RAB9A 311/4885SMN1; SMN2 466/4885 |
| US-20190134206-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | RNASE1, IGF2BP1, IGF2BP2 | NPC1 745/4885RAB9A 311/4885SMN1; SMN2 466/4885 |
| US-20150196655-A1 | CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION | RNASE1, IGF2BP1, IGF2BP2 | NPC1 745/4885RAB9A 311/4885SMN1; SMN2 466/4885 |
| US-11944687-B2 | Carbohydrate conjugate RNA agents and process for their preparation | RNASE1, IGF2BP1, IGF2BP2 | NPC1 725/4885RAB9A 287/4885SMN1; SMN2 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.