Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149607 | 1.00 | RECQL (0.39) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL3143180 | 0.77 | ALDH1A1 (0.35) | RECQLALDH1A1MAPTUSP2GAA | |
| SCHEMBL219983 | 0.77 | — | — | |
| SCHEMBL219982 | 0.77 | — | — | |
| SCHEMBL10149589 | 0.75 | NPC1 (0.32) | ALDH1A1MAPTUSP2NPC1MAPK1 | |
| SCHEMBL328593 | 0.74 | RECQL (0.42) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL454530 | 0.72 | — | — | |
| SCHEMBL454529 | 0.72 | — | — | |
| SCHEMBL9142690 | 0.72 | — | — | |
| SCHEMBL31531962 | 0.70 | ALDH1A1 (0.46) | RECQLALDH1A1MAPTUSP2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897914-B1 | Process for the preparation of 2,5-disubstitued pyridines | HOFFMANN LA ROCHE (CH) | 2004-05-26 | — | — | EP | claimed |
| US-6080866-A | A CHEMICAL INTERMEDIATES FOR ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2000-06-27 | — | — | US | claimed |
| CN-1210105-A | Process for preparation of 2,5-disubstituted pyridines | HOFFMANN LA ROCHE (CH) | 1999-03-10 | — | — | CN | claimed |
| EP-0897914-A1 | Process for the preparation of 2,5-disubstitued pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-24 | — | — | EP | claimed |
| EP-0897914-B1 | Process for the preparation of 2,5-disubstitued pyridines | HOFFMANN LA ROCHE (CH) | 2004-05-26 | — | — | EP | disclosed |
| CN-1103335-C | Process for preparation of 2,5-disubstituted pyridines | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | CN | disclosed |
| US-6080866-A | A CHEMICAL INTERMEDIATES FOR ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2000-06-27 | — | — | US | disclosed |
| CN-1210105-A | Process for preparation of 2,5-disubstituted pyridines | HOFFMANN LA ROCHE (CH) | 1999-03-10 | — | — | CN | disclosed |
| EP-0897914-A1 | Process for the preparation of 2,5-disubstitued pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-24 | — | — | EP | disclosed |
| US-4547594-A | REACTING AND ACYCLIC, OXO, NITRILE WITH METHYL LITHIUM, THEN HYDROLYSIS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4517385-A | FROM ALDEHYDE-NITRILE AND ACETONE, TOBACCO FLABOR | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4489009-A | Process for producing solanone, norsolanadione and intermediates therefor | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-12-18 | — | — | US | disclosed |
| US-4486588-A | Cyclohexadiene carboxylate insecticide intermediates | FMC CORPORATION (US) | 1984-12-04 | — | — | US | disclosed |
| US-4483995-A | ORGANOLEPTIC TOBACCO ADDITIVES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4412083-A | TOBACCO FLAVOR, ORGANOLEPTIC | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1983-10-25 | — | — | US | disclosed |