SCHEMBL10149607

SCHEMBL10149607

CC(C)/C=C/N1CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.39
ALDH1A1 P00352 5/20 0.37
MAPT P10636 4/20 0.37
USP2 O75604 2/20 0.37
ALOX12 P18054 2/20 0.37
GAA P10253 1/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
KCNA5 P22460 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
KMT2A Q03164 1/20 0.32
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582224 1.00 RECQL (0.39) RECQLALDH1A1MAPTUSP2ALOX12
SCHEMBL3143180 0.77 ALDH1A1 (0.35) RECQLALDH1A1MAPTUSP2GAA
SCHEMBL219983 0.77
SCHEMBL219982 0.77
SCHEMBL10149589 0.75 NPC1 (0.32) ALDH1A1MAPTUSP2NPC1MAPK1
SCHEMBL328593 0.74 RECQL (0.42) RECQLALDH1A1MAPTUSP2ALOX12
SCHEMBL454530 0.72
SCHEMBL454529 0.72
SCHEMBL9142690 0.72
SCHEMBL31531962 0.70 ALDH1A1 (0.46) RECQLALDH1A1MAPTUSP2ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2018-01-11 US disclosed
US-9663471-B2 Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORPORATION (US) 2017-05-30 US disclosed
US-20140256780-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORPORATION (US) 2014-09-11 US disclosed
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2014-09-11 US disclosed
US-8772326-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity Anigion Biomedica Corp. (US) 2014-07-08 US disclosed
US-8580834-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2013-11-12 US disclosed
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP 2013-07-25 US disclosed
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-07-26 US disclosed
US-8193177-B2 Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases ANGION BIOMEDICA CORP. (US) 2012-06-05 US disclosed
US-20110230407-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2011-09-22 US disclosed
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2011-07-28 US disclosed
US-7879898-B1 treating a chronic obstructive pulmonary disease using modulators of HGF/SF activity; for example, 3-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one; emphysema ANGION BIOMEDICA CORP. (US) 2011-02-01 US disclosed
US-20100256117-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES ANGION BIOMEDICA CORP. 2010-10-07 US disclosed
US-20080015243-A1 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. 2008-01-17 US disclosed
US-7265112-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2007-09-04 US disclosed
US-7250437-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2007-07-31 US disclosed
US-7192976-B2 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity ANGION BIOMEDICA CORPORATION (US) 2007-03-20 US disclosed
US-4547594-A REACTING AND ACYCLIC, OXO, NITRILE WITH METHYL LITHIUM, THEN HYDROLYSIS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1985-10-15 US disclosed
US-4517385-A FROM ALDEHYDE-NITRILE AND ACETONE, TOBACCO FLABOR INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1985-05-14 US disclosed
US-4486588-A Cyclohexadiene carboxylate insecticide intermediates FMC CORPORATION (US) 1984-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC RECQL 2541/4885ALDH1A1 1510/4885MAPT 4800/4885
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC RECQL 2051/4885ALDH1A1 487/4885MAPT 4579/4885
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC RECQL 2051/4885ALDH1A1 487/4885MAPT 4579/4885
US-20080015243-A1 Small molecule modulators of hepatocyte growth factor (scatter factor) activity HGF, HDGF, MET RECQL 2842/4885ALDH1A1 411/4885MAPT 4360/4885
US-20110230407-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA HGF, HGFAC, HDGF RECQL 2583/4885ALDH1A1 3300/4885MAPT 1281/4885
US-20100256117-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES HGF, HDGF, HGFAC RECQL 4053/4885ALDH1A1 1992/4885MAPT 4274/4885
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC RECQL 2051/4885ALDH1A1 487/4885MAPT 4579/4885
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC RECQL 2025/4885ALDH1A1 380/4885MAPT 4662/4885
US-20140256780-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, MET RECQL 3200/4885ALDH1A1 232/4885MAPT 4188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.