Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.66 |
| ▸ | MMP3 | P08254 | 15/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588431 | 0.92 | MMP2 (0.66) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6584779 | 0.92 | MMP2 (0.65) | MMP2MMP3CCNT1CDK9CYP3A4 | |
| SCHEMBL6582503 | 0.92 | MMP2 (0.55) | MMP2MMP3CCNT1CDK9CYP3A4 | |
| SCHEMBL6588157 | 0.92 | MMP2 (0.70) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6586997 | 0.88 | MMP2 (0.59) | MMP2MMP3CYP3A4CYP2C9PKM | |
| SCHEMBL6584555 | 0.85 | MMP2 (0.63) | MMP2MMP3ADAM10MMP9MMP14 | |
| SCHEMBL6586040 | 0.85 | MMP2 (0.68) | MMP2MMP3ADAM10MMP1MMP9 | |
| SCHEMBL6584396 | 0.84 | MMP2 (0.54) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6586008 | 0.84 | MMP2 (0.58) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6588532 | 0.81 | MMP2 (0.84) | MMP2MMP3CCNT1CDK9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |