Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.54 |
| ▸ | MMP3 | P08254 | 11/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588431 | 0.92 | MMP2 (0.66) | MMP2MMP3CCNT1CDK9GAA | |
| SCHEMBL6582503 | 0.92 | MMP2 (0.55) | MMP2MMP3CCNT1CDK9PTGDR | |
| SCHEMBL6586008 | 0.91 | MMP2 (0.58) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6583989 | 0.89 | MMP2 (0.60) | MMP2MMP3EPHX1ALDH1A1 | |
| SCHEMBL6584555 | 0.84 | MMP2 (0.63) | MMP2MMP3EPHX1GAAADAM10 | |
| SCHEMBL6582426 | 0.84 | MMP2 (0.66) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6588157 | 0.84 | MMP2 (0.70) | MMP2MMP3CCNT1CDK9ADAM10 | |
| SCHEMBL6586997 | 0.82 | MMP2 (0.59) | MMP2MMP3EPHX1GAAADAM10 | |
| SCHEMBL6965353 | 0.81 | MMP2 (0.46) | MMP2MMP3ADAM10ALDH1A1 | |
| SCHEMBL6586078 | 0.81 | MMP2 (0.64) | MMP2MMP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |