Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585890 | 0.97 | DRD2 (0.43) | DRD2HTR1AHTR2AMAOAMAOB | |
| SCHEMBL6585521 | 0.97 | HTR1A (0.42) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL6587330 | 0.97 | DRD2 (0.43) | DRD2HTR1AHTR2AMAOAMAOB | |
| SCHEMBL6585920 | 0.96 | MEN1 (0.43) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL6582756 | 0.95 | DRD2 (0.45) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL6584231 | 0.94 | DRD2 (0.44) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL6583995 | 0.93 | MEN1 (0.46) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL7508996 | 0.86 | DRD4 (0.40) | DRD2HTR1AHTR2ACYP2D6MEN1 | |
| SCHEMBL6583201 | 0.85 | DRD2 (0.41) | DRD2HTR1AHTR2AMEN1MAPT | |
| SCHEMBL6584265 | 0.85 | HTR1A (0.40) | DRD2HTR1AHTR2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |