Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.59 |
| ▸ | HTR6 | P50406 | 5/20 | 0.46 |
| ▸ | HTR3A | P46098 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132413 | 0.89 | ADRB1 (0.54) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| SCHEMBL6132420 | 0.89 | ADRB1 (0.54) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| SCHEMBL6582194 | 0.78 | ADRB1 (0.67) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| SCHEMBL6132417 | 0.76 | ADRB1 (0.56) | ADRB1HTR6HTR3AHTR1AHTR3E | |
| SCHEMBL6132422 | 0.76 | ADRB1 (0.56) | ADRB1HTR6HTR3AHTR1AHTR3E | |
| SCHEMBL29699369 | 0.75 | ADRB1 (1.00) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| SCHEMBL218837 | 0.75 | ADRB1 (1.00) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| Hydrochloric Acid SCHEMBL1894847 | 0.74 | ADRB1 (0.96) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| Iodide SCHEMBL11457680 | 0.74 | ADRB1 (0.96) | ADRB1HTR6HTR3ACYP1A2HTR1A | |
| Hydrochloric Acid SCHEMBL27850954 | 0.74 | ADRB1 (0.96) | ADRB1HTR6HTR3ACYP1A2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246815-B1 | PHENYLPIPERAZINYL DERIVATIVES | LUNDBECK & CO AS H (DK) | 2004-03-17 | — | — | EP | disclosed |
| US-20030083336-A1 | Phenylpiperazinyl derivatives | H. LUNDBECK A/S (DK) | 2003-05-01 | — | — | US | disclosed |
| EP-1246815-A1 | PHENYLPIPERAZINYL DERIVATIVES | H. Lundbeck A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049677-A1 | PHENYLPIPERAZINYL DERIVATIVES | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083336-A1 | Phenylpiperazinyl derivatives | DRD4, DRD2, DRD3 | ADRB1 69/4885HTR6 72/4885HTR3A 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.