Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.67 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR3A | P46098 | 5/20 | 0.50 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149623 | 0.85 | ADRB1 (0.60) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| SCHEMBL31399311 | 0.85 | ADRB1 (0.60) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| SCHEMBL21893900 | 0.80 | ADRB1 (0.62) | ADRB1TSHRHSD17B10 | |
| SCHEMBL218837 | 0.80 | ADRB1 (1.00) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| SCHEMBL29699369 | 0.80 | ADRB1 (1.00) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| Iodide SCHEMBL11457680 | 0.79 | ADRB1 (0.96) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| Hydrochloric Acid SCHEMBL27850954 | 0.79 | ADRB1 (0.96) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| Piperazine SCHEMBL27593403 | 0.79 | ADRB1 (0.96) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| Hydrochloric Acid SCHEMBL1894847 | 0.79 | ADRB1 (0.96) | ADRB1HTR1AHTR3AHTR6CYP1A2 | |
| SCHEMBL6582487 | 0.78 | ADRB1 (0.59) | ADRB1HTR1AHTR3AHTR6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246815-B1 | PHENYLPIPERAZINYL DERIVATIVES | LUNDBECK & CO AS H (DK) | 2004-03-17 | — | — | EP | disclosed |
| CN-1437596-A | Phenylpiperazinyl derivatives | LUNDBECK & CO AS H (DK) | 2003-08-20 | — | — | CN | disclosed |
| US-20030083336-A1 | Phenylpiperazinyl derivatives | H. LUNDBECK A/S (DK) | 2003-05-01 | — | — | US | disclosed |
| US-20030040639-A1 | Method for the preparation of substituted benzene derivatives | H. LUNDBECK A/S (DK) | 2003-02-27 | — | — | US | disclosed |
| EP-1246819-A1 | A METHOD FOR THE PREPARATION OF SUBSTITUTED BENZENE DERIVATIVES | H. Lundbeck A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049681-A1 | A METHOD FOR THE PREPARATION OF SUBSTITUTED BENZENE DERIVATIVES | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083336-A1 | Phenylpiperazinyl derivatives | DRD4, DRD2, DRD3 | ADRB1 69/4885HTR1A 24/4885HTR3A 42/4885 |
| US-20030040639-A1 | Method for the preparation of substituted benzene derivatives | SCLY, CBR3, TST | ADRB1 3918/4885HTR1A 3727/4885HTR3A 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.