Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386679 | 0.90 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL6584578 | 0.85 | KDM4E (0.42) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL9389151 | 0.81 | KDM4E (0.42) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL6584384 | 0.80 | KDM4E (0.51) | ALDH1A1KDM4ENPC1RAB9ALMNA | |
| SCHEMBL9556162 | 0.80 | KDM4E (0.51) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL6580601 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10RAB9ALMNA | |
| SCHEMBL23882575 | 0.75 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10RAB9ALMNA | |
| SCHEMBL9555823 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2180069 | 0.75 | RAB9A (0.63) | ALDH1A1KDM4ENPC1RAB9ALMNA | |
| SCHEMBL6582320 | 0.74 | KDM4E (0.40) | ALDH1A1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |