Sugi Predict

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SCHEMBL6583572

SCHEMBL6583572

Cc1ccc(C)n1-c1cccc(-c2ccc(O)cc2C2CCCC2)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYR P14679 5/20 0.37
▸ ESR1 P03372 3/20 0.34
▸ ESR2 Q92731 2/20 0.34
▸ PIK3CA P42336 3/20 0.34
▸ GAA P10253 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ PIM1 P11309 1/20 0.32
▸ PIM3 Q86V86 1/20 0.32
▸ PIM2 Q9P1W9 1/20 0.32
▸ PDE2A O00408 1/20 0.32
▸ PDE10A Q9Y233 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ GLA P06280 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ CASP1 P29466 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6587036 0.98 TYR (0.37) TYRESR1ESR2PIK3CAGAA
SCHEMBL6583287 0.95 PDE2A (0.35) TYRGAAMEN1NPC1POLB
SCHEMBL27502446 0.80 PDE2A (0.36) TYRGAAMEN1NPC1POLB
SCHEMBL6583443 0.80 ALOX5AP (0.41) MEN1NPC1RAB9AKMT2AFEN1
SCHEMBL8090303 0.79 MEN1 (0.47) TYRESR1ESR2GAAMEN1
SCHEMBL6586756 0.78 ALOX5AP (0.41) MEN1NPC1RAB9AKMT2AFEN1
SCHEMBL6582620 0.77 FEN1 (0.42) ESR1ESR2PIM1PIM3PIM2
SCHEMBL6583717 0.75 ANPEP (0.42) TYRESR1ESR2GAAMEN1
SCHEMBL6588366 0.75 ESR1 (0.43) ESR1ESR2GAAMEN1POLB
SCHEMBL6581983 0.75 MEN1 (0.41) MEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1523015-A 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines �Ʒ� 2004-08-25 — — CN disclosed
CN-1515554-A Intermediate compound for producing 2-amino-6-(2-substituted-4-phenoxy) substituted pyridine compound �Ʒ� 2004-07-28 — — CN disclosed
EP-0958282-B1 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES PFIZER PROD INC (US) 2004-07-21 — — EP disclosed
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders PFIZER INC. 2003-08-28 — — US disclosed
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... PFIZER INC. 2001-07-12 — — US disclosed
CN-1246848-A 2-amino-6- (2-substituted-4-phenoxy) -substituted pyridines PFIZER PROD INC (US) 2000-03-08 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... NOS1, PTGS1, NOS2 TYR 1395/4885ESR1 1823/4885ESR2 1113/4885
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders GRIN2C, GRIN2A, CNR2 TYR 1571/4885ESR1 2452/4885ESR2 661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.