Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9653164 | 0.92 | ADRB1 (0.52) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL9653685 | 0.87 | ADRB1 (0.51) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL9653135 | 0.86 | ADRB1 (0.50) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL9389280 | 0.86 | ADRB1 (0.52) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL6588799 | 0.84 | DRD2 (0.61) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL18072426 | 0.79 | ADRB2 (0.54) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL8054602 | 0.78 | ALDH1A1 (0.46) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL9390026 | 0.78 | DRD2 (0.61) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL885653 | 0.78 | MAPT (0.49) | ADRB1ADRB2HTR1AOPRK1MAPT | |
| SCHEMBL30335516 | 0.78 | ADRB1 (0.50) | DRD2DRD4DRD3ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |