Sugi Predict

Sugi Predict / Compounds / SCHEMBL6586756

SCHEMBL6586756

SCHEMBL6586756

Cc1ccc(C)n1-c1cccc(-c2ccc(OCc3ccccc3)cc2C2CCC2)n1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALOX5AP P20292 5/20 0.41
▸ FEN1 P39748 5/20 0.41
▸ HRH3 Q9Y5N1 3/20 0.41
▸ CYP2D6 P10635 2/20 0.41
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ IGF1R P08069 3/20 0.39
▸ FFAR1 O14842 1/20 0.37
▸ ALOX5 P09917 1/20 0.37
▸ MAOA P21397 3/20 0.37
▸ MAOB P27338 3/20 0.37
▸ HTR2B P41595 1/20 0.37
▸ TMEM97 Q5BJF2 1/20 0.37
▸ SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6583443 0.98 ALOX5AP (0.41) ALOX5APFEN1HRH3CYP2D6MEN1
SCHEMBL6581983 0.96 MEN1 (0.41) HRH3CYP2D6MEN1NPC1RAB9A
SCHEMBL8093800 0.83 NPC1 (0.45) MEN1NPC1RAB9AKMT2AFFAR1
SCHEMBL6581790 0.81 MAOB (0.44) MEN1NPC1RAB9AKMT2AALOX5
SCHEMBL6587036 0.80 TYR (0.37) ALOX5APFEN1MEN1NPC1RAB9A
SCHEMBL6583572 0.78 TYR (0.37) FEN1MEN1NPC1RAB9AKMT2A
SCHEMBL6152763 0.77 NOS3 (0.48) —
SCHEMBL7977384 0.76 SLC6A2 (0.42) ALOX5APFEN1RAB9AIGF1RALOX5
SCHEMBL6583287 0.75 PDE2A (0.35) MEN1NPC1RAB9AKMT2AMAOA
SCHEMBL5833356 0.74 NOS3 (0.43) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1523015-A 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines �Ʒ� 2004-08-25 — — CN disclosed
CN-1515554-A Intermediate compound for producing 2-amino-6-(2-substituted-4-phenoxy) substituted pyridine compound �Ʒ� 2004-07-28 — — CN disclosed
EP-0958282-B1 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES PFIZER PROD INC (US) 2004-07-21 — — EP disclosed
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders PFIZER INC. 2003-08-28 — — US disclosed
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... PFIZER INC. 2001-07-12 — — US disclosed
CN-1246848-A 2-amino-6- (2-substituted-4-phenoxy) -substituted pyridines PFIZER PROD INC (US) 2000-03-08 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... NOS1, PTGS1, NOS2 ALOX5AP 251/4885FEN1 3816/4885HRH3 1109/4885
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders GRIN2C, GRIN2A, CNR2 ALOX5AP 1604/4885FEN1 4809/4885HRH3 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.