Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.43 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12670823 | 0.79 | FBP1 (0.56) | LMNAPIN1POLBSMN1; SMN2KMT2A | |
| SCHEMBL5576457 | 0.74 | MAPT (0.44) | LMNAPIN1POLBSMN1; SMN2KMT2A | |
| SCHEMBL11368040 | 0.74 | POLB (0.49) | LMNAPOLBSMN1; SMN2KMT2AMAPT | |
| SCHEMBL7324343 | 0.74 | CA12 (0.42) | LMNAPOLBSMN1; SMN2MAPTGAA | |
| SCHEMBL7861235 | 0.71 | ALDH1A1 (0.48) | LMNAMAPTALDH1A1RECQLL3MBTL1 | |
| SCHEMBL7860078 | 0.70 | ALDH1A1 (0.47) | PIN1SMN1; SMN2KMT2AMAPTALDH1A1 | |
| SCHEMBL9199837 | 0.70 | ALDH1A1 (0.47) | LMNAPIN1POLBSMN1; SMN2MAPT | |
| SCHEMBL16672585 | 0.70 | CNR2 (0.49) | LMNAPIN1POLBKMT2AMAPT | |
| SCHEMBL13846168 | 0.70 | HSD17B10 (0.46) | LMNAPOLBSMN1; SMN2KMT2AMAPT | |
| SCHEMBL6989689 | 0.70 | HSD17B10 (0.62) | LMNAPOLBSMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897914-B1 | Process for the preparation of 2,5-disubstitued pyridines | HOFFMANN LA ROCHE (CH) | 2004-05-26 | — | — | EP | disclosed |
| US-6080866-A | A CHEMICAL INTERMEDIATES FOR ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0897914-A1 | Process for the preparation of 2,5-disubstitued pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-24 | — | — | EP | disclosed |