Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | C1R | P00736 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050237 | 0.82 | TSHR (0.36) | KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL6304704 | 0.76 | SIGMAR1 (0.36) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2092778 | 0.76 | GRIK1 (0.37) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6045282 | 0.72 | — | — | |
| SCHEMBL31126634 | 0.72 | — | — | |
| SCHEMBL8872909 | 0.71 | MAPT (0.48) | KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL3184890 | 0.71 | RAB9A (0.45) | — | |
| SCHEMBL2197479 | 0.71 | GAA (0.46) | KDM4EHPGDHSD17B10 | |
| SCHEMBL27884179 | 0.71 | KDM4E (0.52) | KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL9463502 | 0.71 | RAB9A (0.41) | KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | LABORATOIRES FOURNIER S.A. (FR) | 2004-07-15 | — | — | US | disclosed |
| EP-1387826-A1 | NOVEL 5-PHENYL-1H-INDOLE DERIVATIVES AS ANTAGONISTS OF INTERLEUKINE-8 RECEPTORS | LABORATOIRES FOURNIER S.A. (FR) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002092567-A1 | NOVEL 5-PHENYL-1H-INDOLE DERIVATIVES AS ANTAGONISTS OF INTERLEUKINE-8 RECEPTORS | LABORATOIRES FOURNIER SA (FR) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | CXCL8, IL1RN, CCR8 | SIGMAR1 552/4885GRIN2D 1369/4885GRIN3B 2654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.