SCHEMBL6584924

SCHEMBL6584924

Clc1ccc(OC2CN(C(c3ccccc3)c3ccccc3)C2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.49
ADRA2A P08913 3/20 0.49
ADRA1A P35348 3/20 0.49
DRD3 P35462 3/20 0.49
KCNH2 Q12809 3/20 0.49
SLC6A4 P31645 3/20 0.49
HTR1A P08908 2/20 0.49
CHRM1 P11229 2/20 0.49
DRD1 P21728 2/20 0.49
TBXA2R P21731 2/20 0.49
SLC6A2 P23975 2/20 0.49
SLC6A3 Q01959 2/20 0.49
BCL2 P10415 1/20 0.49
HRH3 Q9Y5N1 1/20 0.49
CYP2D6 P10635 3/20 0.48
TSHR P16473 1/20 0.48
CYP2C19 P33261 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
OPRM1 P35372 3/20 0.44
OPRK1 P41145 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1769006 0.89 SLC6A3 (0.46) CHRM2ADRA2ADRD3KCNH2SLC6A4
SCHEMBL4311250 0.86 ACHE (0.43) CHRM2ADRA2ADRD3KCNH2CHRM1
SCHEMBL518041 0.86 NAAA (0.56) CHRM2ADRA2ADRD3KCNH2CHRM1
SCHEMBL10808078 0.84 OPRM1 (0.44) CHRM2ADRA2ADRD3KCNH2CHRM1
SCHEMBL10804626 0.84 OPRM1 (0.52) CYP2D6OPRM1OPRK1OPRD1OPRL1
SCHEMBL9596982 0.84 OPRM1 (0.44) CHRM2ADRA2ADRD3KCNH2SLC6A4
SCHEMBL795699 0.84 ACHE (0.45) OPRM1OPRK1OPRD1OPRL1MEN1
SCHEMBL5219952 0.84 HRH1 (0.51) KCNH2SLC6A4SLC6A2SLC6A3OPRK1
SCHEMBL1740319 0.84 SLC6A4 (0.47) KCNH2SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL5803956 0.81 ACHE (0.41) CHRM2ADRA2AADRA1ADRD3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1049671-B1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RES LTD (GB) 2004-04-21 EP disclosed
US-6514961-B1 Such as anxiety and all forms of epilepsy, particularly in humans VERNALIS RESEARCH LIMITED (GB) 2003-02-04 US disclosed
EP-1196166-A1 AZETIDINE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2002-04-17 EP disclosed
WO-2001007043-A1 AZETIDINE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2001-02-01 WO disclosed
EP-1049671-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2000-11-08 EP disclosed
WO-1999037614-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 1999-07-29 WO disclosed
EP-0560905-A1 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY. ROBINS CO INC A H (US) 1993-09-22 EP disclosed
US-5183902-A Muscle relaxants A. H. ROBINS COMPANY, INCORPORATED (US) 1993-02-02 US disclosed
US-5151418-A Muscle relaxants A. H. ROBINS COMPANY, INCORPORATED (US) 1992-09-29 US disclosed
WO-1992010474-A1 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY A.H. ROBINS COMPANY, INCORPORATED (US) 1992-06-25 WO disclosed
US-5095014-A 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides having anticonvulsant activity A. H. ROBINS COMPANY, INCORPORATED (US) 1992-03-10 US disclosed
US-5068231-A Ureas and thioureas for relaxing muscles A. H. ROBINS COMPANY INCORPORATED (US) 1991-11-26 US disclosed
US-4956359-A CARBOXAMIDES OR THIOCARBOXAMIDES OF ARYL OXY OR THIO AZETIDINES A. H. ROBINS COMPANY, INC. (US) 1990-09-11 US disclosed