Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 4/20 | 0.74 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583574 | 0.85 | MMP3 (1.00) | MMP3NAAAMMP2 | |
| SCHEMBL6584929 | 0.76 | MMP3 (0.72) | MMP3GAAMMP2ALDH1A1LMNA | |
| SCHEMBL6590060 | 0.74 | MMP3 (0.73) | MMP3MMP2ALDH1A1 | |
| SCHEMBL3414409 | 0.71 | NAAA (0.58) | MMP3NAAAACACBEPHX2ALDH1A1 | |
| SCHEMBL6586496 | 0.71 | MMP2 (0.69) | MMP3MMP2ALDH1A1 | |
| SCHEMBL6588226 | 0.69 | MMP3 (0.60) | MMP3MMP2ALDH1A1MAPT | |
| SCHEMBL6590110 | 0.69 | MMP3 (0.76) | MMP3ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL518106 | 0.68 | NAMPT (0.56) | MMP3NAAAEPHX2 | |
| SCHEMBL25094668 | 0.67 | KDM4E (0.58) | ALDH1A1LMNATSHR | |
| SCHEMBL22174136 | 0.66 | NAAA (0.51) | MMP3NAAAEPHX2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |