Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979240 | 0.88 | CYP4F2 (0.60) | LTA4HEPHX2FFAR1BCHECYP4F2 | |
| SCHEMBL10554538 | 0.77 | PRMT5 (0.50) | LTA4HEPHX2FFAR1FFAR4CYP4F2 | |
| SCHEMBL1563277 | 0.76 | LTA4H (1.00) | LTA4HEPHX2FFAR1FFAR4ALOX5 | |
| SCHEMBL5700 | 0.76 | LTA4H (0.80) | LTA4HEPHX2FFAR1FFAR4BCHE | |
| SCHEMBL6585897 | 0.75 | CYP4F2 (0.48) | LTA4HEPHX2FFAR1BCHECYP4F2 | |
| SCHEMBL11687518 | 0.74 | LTA4H (0.97) | LTA4HEPHX2FFAR1FFAR4ALOX5 | |
| SCHEMBL5760428 | 0.74 | LTA4H (0.90) | LTA4HEPHX2FFAR1FFAR4ALOX5 | |
| SCHEMBL10405807 | 0.73 | LTA4H (0.87) | LTA4HEPHX2FFAR1FFAR4ALOX5 | |
| SCHEMBL7367359 | 0.73 | LTA4H (0.87) | LTA4HEPHX2FFAR1FFAR4ALOX5 | |
| SCHEMBL9254006 | 0.73 | LTA4H (0.87) | LTA4HEPHX2FFAR1FFAR4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116330-A1 | Diagnosing or specifying a growth factor receptor expressed in cancer cells, and selectively inhibiting all or a part of the growth factor receptor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1268473-A1 | OXAZOLE DERIVATIVES AND THEIR USES AS TYROSINE KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001077107-A1 | OXAZOLE DERIVATIVES AND THEIR USES AS TYROSINE KINASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-18 | — | — | WO | disclosed |