Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15475871 | 0.86 | KDM4E (0.48) | KDM4EPKMSTSMAPTNPC1 | |
| SCHEMBL5403405 | 0.83 | KDM4E (0.54) | KDM4EPKMSTSJAK2JAK1 | |
| SCHEMBL20281446 | 0.82 | KDM4E (0.44) | KDM4EPKMSTSMAPTNPC1 | |
| SCHEMBL6584233 | 0.81 | KDM4E (0.51) | KDM4EPKMSTSJAK2JAK1 | |
| SCHEMBL3979358 | 0.80 | KDM4E (0.57) | KDM4EPKMSTSTGFBR1HTT | |
| SCHEMBL22594810 | 0.79 | KDM4E (0.59) | KDM4EPKMKDM1ATGFBR1HTR6 | |
| SCHEMBL6585898 | 0.78 | GPR119 (0.48) | KDM4EPKM | |
| SCHEMBL4326217 | 0.78 | KDM4E (0.60) | KDM4EPKMSTSKDM1ATGFBR1 | |
| SCHEMBL388491 | 0.78 | KDM4E (0.47) | KDM4EPKM | |
| SCHEMBL24765850 | 0.77 | VEGFA (0.48) | STSKDM1AMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455788-A1 | 1-GLYCINYL-4-AMINOMETHYL-PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049737-A1 | CHEMICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |