Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177213 | 0.88 | ADORA2A (0.50) | IKBKBBCAT2PARP1ADORA2ABRD4 | |
| SCHEMBL27605296 | 0.87 | ACMSD (0.53) | DHODHKMOACMSDIP6K1IP6K3 | |
| SCHEMBL27624326 | 0.74 | ACMSD (0.47) | DHODHACMSDUCHL5 | |
| SCHEMBL27355083 | 0.74 | ADORA2A (0.42) | IKBKBBCAT2MKNK1MKNK2ADORA2A | |
| SCHEMBL14901086 | 0.73 | ALDH1A1 (0.46) | ACMSDADORA2AUCHL5 | |
| Hydrochloric Acid SCHEMBL7201470 | 0.73 | MCL1 (0.53) | UCHL5 | |
| SCHEMBL28353842 | 0.73 | BCAT2 (0.75) | IKBKBDHODHSIRT2SIRT1KMO | |
| Water SCHEMBL27300806 | 0.73 | ADORA2A (0.41) | IKBKBBCAT2MKNK1MKNK2ADORA2A | |
| SCHEMBL27688880 | 0.72 | BCAT2 (0.58) | IKBKBDHODHSIRT2SIRT1KMO | |
| SCHEMBL8315867 | 0.71 | ALDH1A1 (0.43) | IKBKBDHODHPARP1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448513-A1 | BIPHENYL-DERIVATIVES AS P38-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-08-25 | — | — | EP | disclosed |
| EP-1435934-A1 | 5'-ACYLAMINO-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| EP-1436272-A1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033457-A1 | BIPHENYL-DERIVATIVES AS P38-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003033483-A1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003032971-A1 | 5’-ACYLAMINO-1,1’-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |