Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.62 |
| ▸ | DHODH | Q02127 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31157024 | 1.00 | KDM4E (0.62) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL31214767 | 0.86 | NCOA1 (0.59) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL28005852 | 0.86 | NPC1 (0.48) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL6586825 | 0.82 | KDM4E (0.68) | KDM4ELMNASMN1; SMN2DHODHPOLB | |
| SCHEMBL29359819 | 0.81 | KDM4E (0.83) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL18746 | 0.81 | KDM4E (0.83) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL662652 | 0.79 | KDM4E (0.64) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL374556 | 0.79 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| Potassium SCHEMBL93448 | 0.79 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL69125 | 0.79 | KDM4E (0.64) | KDM4ELMNASMN1; SMN2PDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1150977-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047577-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |