Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 9/20 | 0.42 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | WNT1 | P04628 | 3/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589131 | 0.90 | AURKB (0.40) | PRKCZPARP1PARP2 | |
| SCHEMBL6590870 | 0.89 | AURKB (0.51) | PARP1 | |
| SCHEMBL6587212 | 0.86 | AURKA (0.50) | PARP1 | |
| SCHEMBL6805985 | 0.85 | PARP1 (0.56) | PRKCZPARP1PARP2 | |
| SCHEMBL6583719 | 0.83 | PARP1 (0.43) | PARP1 | |
| SCHEMBL6587697 | 0.82 | AURKB (0.44) | PARP1 | |
| SCHEMBL6587758 | 0.80 | PARP1 (0.57) | PRKCZPARP1PARP2 | |
| SCHEMBL6587920 | 0.80 | PARP1 (0.46) | PRKCZPARP1PARP2 | |
| SCHEMBL6581295 | 0.79 | AURKB (0.56) | PRKCZPARP1PARP2 | |
| SCHEMBL6874969 | 0.78 | PARP1 (0.51) | PARP1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |