Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587758 | 0.86 | PARP1 (0.57) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6806427 | 0.82 | PKN1 (0.67) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6590709 | 0.82 | PKN1 (0.66) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6588724 | 0.81 | PDE5A (0.51) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6586688 | 0.81 | PKN1 (0.68) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6590890 | 0.80 | METAP2 (0.50) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6585966 | 0.80 | PKN2 (0.48) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6586196 | 0.80 | BRD4 (0.44) | PARP1PRKCZPARP2 | |
| SCHEMBL6585579 | 0.79 | PKN2 (0.43) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6586038 | 0.78 | PIM1 (0.51) | PARP1PKN1PKN2PLK4MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |