SCHEMBL6586502

SCHEMBL6586502

CC(C)(C)c1cccc2c1SCC2

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.39
ALDH1A1 P00352 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HTR1A P08908 1/20 0.35
ADRA2A P08913 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRB2 P47870 1/20 0.34
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
FOLH1 Q04609 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11893068 0.82 ALDH1A1 (0.35) ALDH1A1L3MBTL1HTR1AADRA2ASLC6A2
SCHEMBL22004794 0.75 ALDH1A1 (0.38) CA2ALDH1A1L3MBTL1KIF11
SCHEMBL8290712 0.74 MEN1 (0.38) CA2ALDH1A1L3MBTL1HTR1AADRA2A
SCHEMBL18297683 0.71
SCHEMBL17307160 0.70 CA2 (0.36) CA2ALDH1A1GABRA1GABRB2TSHR
SCHEMBL23720947 0.69 HTR1A (0.31) ALDH1A1L3MBTL1HTR1AADRA2ASLC6A2
SCHEMBL10816476 0.69 KDM4E (0.41) ALDH1A1TSHRTDP1
SCHEMBL13972198 0.69 KDM1A (0.30)
SCHEMBL10816016 0.69 BCL2L1 (0.42) CA2ALDH1A1L3MBTL1HTR1AADRA2A
SCHEMBL18932521 0.69 CA2 (0.39) CA2ALDH1A1L3MBTL1GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0891346-B1 DIHYDROBENZOFURAN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS UNIV VANDERBILT (US) 2004-05-12 EP disclosed
EP-0891346-A1 DIHYDROBENZOFURAN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS THE PROCTER & GAMBLE COMPANY (US) 1999-01-20 EP disclosed
US-5672620-A ANALGESICS, ANTIARTHRITIC AGENT THE PROCTER & GAMBLE COMPANY (US) 1997-09-30 US disclosed
WO-1997028148-A1 DIHYDROBENZOFURAN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS THE PROCTER & GAMBLE COMPANY (US) 1997-08-07 WO disclosed