Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563835 | 0.86 | MAPT (0.41) | MAPTL3MBTL1CRHR1NR4A2MEN1 | |
| SCHEMBL2871982 | 0.83 | MAPT (0.57) | MAPTL3MBTL1CRHR1NR4A2KMT2A | |
| SCHEMBL3051550 | 0.78 | MAPT (0.60) | MAPTL3MBTL1CRHR1NR4A2MEN1 | |
| SCHEMBL6590908 | 0.77 | METAP2 (0.36) | MAPTL3MBTL1KMT2A | |
| SCHEMBL439728 | 0.77 | NR4A2 (0.42) | MAPTNR4A2LMNA | |
| SCHEMBL2937315 | 0.76 | MAPT (0.49) | MAPTL3MBTL1CRHR1MEN1KMT2A | |
| SCHEMBL17825675 | 0.74 | LMNA (0.38) | CRHR1MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL8123570 | 0.72 | GPR35 (0.49) | — | |
| SCHEMBL9730943 | 0.71 | MAPT (0.47) | MAPTL3MBTL1CRHR1NR4A2LMNA | |
| SCHEMBL331909 | 0.71 | TDP1 (0.33) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1150977-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047577-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |