SCHEMBL6587313

SCHEMBL6587313

Cn1cncc1C(Oc1ccc(Cl)cc1)c1ccc2[nH]cc(-c3cccc(Cl)c3)c2c1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FNTA P49354 15/20 0.49
FNTB P49356 15/20 0.49
PGGT1B P53609 8/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7762145 0.88 FNTA (0.58) FNTAFNTBPGGT1B
SCHEMBL7707732 0.81 FNTA (0.76) FNTAFNTBPGGT1B
SCHEMBL6586870 0.72 FNTA (0.77) FNTAFNTBPGGT1B
SCHEMBL8181649 0.71 FNTA (0.67) FNTAFNTBPGGT1B
SCHEMBL6010464 0.70 FNTA (0.60) FNTAFNTBPGGT1B
SCHEMBL8872044 0.69 EGFR (0.55)
SCHEMBL5778239 0.67 FNTA (0.68) FNTAFNTBPGGT1B
SCHEMBL7509771 0.67 PIM1 (0.47)
SCHEMBL5733786 0.66 FNTA (1.00) FNTAFNTB
SCHEMBL13186537 0.66 FNTA (1.00) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097150-B1 IMIDAZOLYL DERIVATIVES CONSEILS DE RECH SET D APPLIC (FR) 2004-03-24 EP disclosed
US-20040002531-A1 Imidazolyl derivatives SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTEFIQUES, S.A.S., A FRANCE CORPORATION 2004-01-01 US disclosed
US-6509336-B1 Prenyl transeferase inhibitors SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) 2003-01-21 US disclosed
US-20030004342-A1 Imidazolyl derivatives BIOMEASURE, INC., A MASSACHUSETTS CORPORATION 2003-01-02 US disclosed
US-6420555-B1 IMIDAZOLE DERIVATIVES PRENYL TRANSFERASE INHIBITORS. SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) 2002-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030004342-A1 Imidazolyl derivatives TPI1, BCHE, CYP51A1 FNTA 51/4885FNTB 184/4885PGGT1B 1091/4885
US-20040002531-A1 Imidazolyl derivatives TPI1, BCHE, CYP51A1 FNTA 51/4885FNTB 184/4885PGGT1B 1091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.