Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SI | P14410 | 3/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585205 | 0.87 | PARP1 (0.42) | PARP1LMNAMGAMGAASI | |
| SCHEMBL6587656 | 0.87 | PARP1 (0.38) | PARP1 | |
| SCHEMBL6804441 | 0.86 | PARP1 (0.55) | PARP1 | |
| SCHEMBL6587520 | 0.82 | PARP1 (0.46) | PARP1LMNAMGAMGAASI | |
| SCHEMBL6589144 | 0.81 | PARP1 (0.42) | PARP1LMNAMGAMGAASI | |
| SCHEMBL6587124 | 0.77 | PARP1 (0.43) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL6804448 | 0.75 | GRM2 (0.38) | PARP1LMNACNR1PPARAALOX12 | |
| SCHEMBL6588299 | 0.74 | PARP1 (0.47) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL6585330 | 0.73 | PARP1 (0.43) | PARP1KMT2A | |
| SCHEMBL6807418 | 0.73 | PARP1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |