Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587656 | 0.91 | PARP1 (0.38) | PARP1MALT1FLT3 | |
| SCHEMBL6802778 | 0.86 | PARP1 (0.61) | PARP1 | |
| SCHEMBL6587344 | 0.81 | PARP1 (0.43) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6807418 | 0.77 | PARP1 (0.53) | PARP1 | |
| SCHEMBL6587569 | 0.77 | PARP1 (0.39) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6802788 | 0.75 | PARP1 (0.41) | PARP1FGFR1SRCFGFR2FGFR4 | |
| SCHEMBL6587520 | 0.74 | PARP1 (0.46) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6585205 | 0.74 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6589144 | 0.73 | PARP1 (0.42) | PARP1FGFR1FGFR2FGFR3GAA | |
| SCHEMBL6587920 | 0.69 | PARP1 (0.46) | PARP1GAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |