SCHEMBL6587608

SCHEMBL6587608

Cc1nc(N(C)C2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)nc(N)c1C

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.48
KCNH2 Q12809 8/20 0.47
CYP3A4 P08684 2/20 0.45
GPR119 Q8TDV5 7/20 0.44
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
DNMT1 P26358 1/20 0.42
EHMT2 Q96KQ7 1/20 0.42
ACHE P22303 2/20 0.42
BCHE P06276 1/20 0.42
BACE1 P56817 1/20 0.42
PDE8B O95263 1/20 0.40
DRD4 P21917 1/20 0.40
TEAD1 P28347 1/20 0.40
PARP1 P09874 1/20 0.39
PARP2 Q9UGN5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6593408 0.89 SLC2A1 (0.52) SLC2A1KCNH2ALDH1A1ACHEBACE1
SCHEMBL6597276 0.87 SLC2A1 (0.62) SLC2A1CYP3A4ALDH1A1ACHEDRD4
SCHEMBL6588987 0.81 SLC2A1 (0.53) SLC2A1KDM4EALDH1A1ACHEBACE1
SCHEMBL6592239 0.76 CYP3A4 (0.49) KCNH2CYP3A4GPR119KDM4EALDH1A1
SCHEMBL14242820 0.72 HRH3 (0.67) KCNH2CYP3A4KDM4EALDH1A1ACHE
Ammonia Solution, Strong SCHEMBL28813879 0.71 HRH3 (0.65) KCNH2CYP3A4GPR119KDM4EALDH1A1
SCHEMBL2842619 0.69 KCNH2 (0.58) KCNH2GPR119DNMT1EHMT2TEAD1
SCHEMBL8109237 0.69 KDM4E (0.65) KCNH2CYP3A4KDM4EALDH1A1ACHE
SCHEMBL6941820 0.69 KDM4E (0.65) KCNH2CYP3A4KDM4EALDH1A1ACHE
SCHEMBL1873833 0.67 RORC (0.47) KCNH2CYP3A4GPR119KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912552-B1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2004-04-21 EP claimed
EP-0912552-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1999-05-06 EP claimed
WO-1997043279-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-20 WO claimed
EP-0912552-B1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2004-04-21 EP disclosed
EP-0912552-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1999-05-06 EP disclosed
WO-1997043279-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-20 WO disclosed