Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | GMNN | O75496 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 5/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593408 | 0.91 | SLC2A1 (0.52) | SLC2A1ACHEDRD2DRD4DRD3 | |
| SCHEMBL6588987 | 0.89 | SLC2A1 (0.53) | SLC2A1ACHEDRD4ALDH1A1SCN1A | |
| SCHEMBL6587608 | 0.87 | SLC2A1 (0.48) | SLC2A1ACHEDRD4ALDH1A1CYP3A4 | |
| SCHEMBL6593436 | 0.79 | SLC2A1 (0.56) | SLC2A1ACHEDRD2DRD4DRD3 | |
| SCHEMBL21375648 | 0.74 | SIGMAR1 (0.60) | ACHEDRD2DRD4DRD3GMNN | |
| SCHEMBL19311894 | 0.72 | ACHE (0.62) | ACHEDRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL8406887 | 0.72 | DRD2 (0.51) | SLC2A1ACHEDRD2DRD4DRD3 | |
| SCHEMBL2108897 | 0.72 | ACHE (0.66) | ACHEDRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL8408498 | 0.71 | DRD2 (0.67) | SLC2A1ACHEDRD2DRD4DRD3 | |
| SCHEMBL16346811 | 0.71 | DRD2 (0.53) | SLC2A1ACHEDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912552-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2004-04-21 | — | — | EP | disclosed |
| US-6395742-B1 | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-28 | — | — | US | disclosed |