SCHEMBL6593408

SCHEMBL6593408

Cc1ccc(CN2CCC(N(C)c3nc(C)c(C)c(N)n3)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.52
ACHE P22303 3/20 0.40
F2R P25116 1/20 0.40
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
BACE1 P56817 1/20 0.39
TEAD1 P28347 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
HRH1 P35367 2/20 0.39
CYP2D6 P10635 1/20 0.39
KCNH2 Q12809 1/20 0.39
DRD4 P21917 2/20 0.38
CHIT1 Q13231 1/20 0.38
CHIA Q9BZP6 1/20 0.38
DRD2 P14416 1/20 0.37
DRD1 P21728 1/20 0.37
HTR2A P28223 1/20 0.37
DRD3 P35462 1/20 0.37
SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6597276 0.91 SLC2A1 (0.62) SLC2A1ACHEALDH1A1LMNAHRH3
SCHEMBL6587608 0.89 SLC2A1 (0.48) SLC2A1ACHEALDH1A1BACE1TEAD1
SCHEMBL6588987 0.87 SLC2A1 (0.53) SLC2A1ACHEALDH1A1BACE1DRD4
SCHEMBL12074554 0.74 ALDH1A1 (0.56) ACHEALDH1A1LMNAPOLBBACE1
SCHEMBL6593436 0.70 SLC2A1 (0.56) SLC2A1ACHEALDH1A1LMNAHRH3
SCHEMBL17753018 0.69 MEN1 (0.50) ACHEALDH1A1LMNAPOLBBACE1
SCHEMBL8275450 0.69 HRH3 (0.76) ACHEALDH1A1LMNAPOLBBACE1
SCHEMBL18516568 0.69 LTA4H (0.55) ACHEALDH1A1LMNAPOLBBACE1
SCHEMBL14924455 0.69 LTA4H (0.55) ACHEALDH1A1LMNAPOLBBACE1
SCHEMBL19671026 0.69 ALDH1A1 (0.57) ACHEALDH1A1LMNAPOLBBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912552-B1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2004-04-21 EP claimed
EP-0912552-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1999-05-06 EP claimed
WO-1997043279-A1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-20 WO claimed
EP-0912552-B1 2,4-DIAMINOPYRIMIDINE DERIVATES AS DOPAMINE D4 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2004-04-21 EP disclosed
US-6395742-B1 PSYCHOLOGICAL DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 2002-05-28 US disclosed