Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587827 | 0.81 | MAPT (0.49) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL6589440 | 0.81 | NLRP3 (0.58) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2954499 | 0.81 | L3MBTL1 (0.61) | GAAKMT2AMEN1LMNAMAPT | |
| SCHEMBL6587221 | 0.80 | P2RY14 (0.55) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL6587745 | 0.80 | KMT2A (0.56) | GAAKMT2AMEN1LMNAMAPT | |
| SCHEMBL6586514 | 0.77 | RAB9A (0.48) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6588756 | 0.76 | SMN1; SMN2 (0.56) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL6198851 | 0.75 | GAA (0.57) | GAAKMT2AMEN1LMNAMAPT | |
| SCHEMBL391522 | 0.73 | GAA (0.73) | GAAKMT2AMEN1LMNAMAPT | |
| SCHEMBL6587091 | 0.73 | KIT (0.50) | KMT2AMEN1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |