Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589442 | 0.82 | NLRP3 (0.61) | KMT2AMEN1LMNASMN1; SMN2HTT | |
| SCHEMBL6587830 | 0.81 | MEN1 (0.47) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL6587743 | 0.80 | GAA (0.57) | KMT2AMEN1MAPTLMNAGAA | |
| SCHEMBL6587226 | 0.79 | USP2 (0.56) | KMT2AMEN1MAPTLMNAHTT | |
| SCHEMBL6586518 | 0.78 | RAB9A (0.47) | LMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6588758 | 0.76 | SMN1; SMN2 (0.58) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL2954499 | 0.76 | L3MBTL1 (0.61) | KMT2AMEN1MAPTLMNAGAA | |
| SCHEMBL6590589 | 0.74 | ALDH1A1 (0.40) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL391522 | 0.74 | GAA (0.73) | KMT2AMEN1MAPTLMNAGAA | |
| SCHEMBL6587095 | 0.72 | ROCK2 (0.49) | MAPTSMN1; SMN2HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |