Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 7/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6591485 | 0.94 | CAMK2D (0.44) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6589561 | 0.94 | CAMK2D (0.50) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6585782 | 0.93 | CAMK2D (0.45) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6588255 | 0.91 | CAMK2D (0.43) | CAMK2DPIM1 | |
| Trifluoroacetic Acid SCHEMBL6586548 | 0.90 | CAMK2D (0.50) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6588330 | 0.90 | CAMK2D (0.43) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6586721 | 0.88 | CAMK2D (0.43) | CAMK2DPIM1CA12CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL6588835 | 0.87 | CHEK1 (0.39) | CAMK2DPIM1CDK2 | |
| SCHEMBL6588231 | 0.86 | CAMK2D (0.51) | CAMK2DPIM1 | |
| Trifluoroacetic Acid SCHEMBL6591980 | 0.86 | ICMT (0.37) | CAMK2DPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |