Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.59 |
| ▸ | CBFB | Q13951 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585381 | 0.82 | CBFB (0.67) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL6806558 | 0.82 | ADORA3 (0.63) | ADORA3ADORA1ADORA2APARP1DHODH | |
| SCHEMBL6590890 | 0.80 | METAP2 (0.50) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL6585540 | 0.77 | CBFB (0.47) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL6585207 | 0.76 | PARP1 (0.51) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL31061052 | 0.75 | ADORA3 (1.00) | ADORA3ADORA1ADORA2ACBFBALDH1A1 | |
| SCHEMBL31060640 | 0.75 | ADORA3 (1.00) | ADORA3ADORA1ADORA2ACBFB | |
| SCHEMBL6589950 | 0.75 | PKN1 (0.46) | ALOX15PARP1HPSEDHODHPARP2 | |
| SCHEMBL6590709 | 0.74 | PKN1 (0.66) | ALOX15PARP1HPSEDHODHPARP2 | |
| SCHEMBL6590776 | 0.74 | PARP1 (0.46) | CBFBALDH1A1TP53CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |