Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 9/20 | 0.49 |
| ▸ | QDPR | P09417 | 3/20 | 0.47 |
| ▸ | KHK | P50053 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584948 | 0.83 | SIGMAR1 (0.65) | SIGMAR1HTR2CQDPRKHKHTR6 | |
| SCHEMBL4670817 | 0.82 | SIGMAR1 (0.57) | SIGMAR1HTR2CQDPRKHKHTR6 | |
| SCHEMBL6586022 | 0.80 | SIGMAR1 (0.52) | SIGMAR1HTR2CQDPRHTR6HTR7 | |
| SCHEMBL16434840 | 0.79 | HTR2C (0.57) | SIGMAR1HTR2CQDPRKHKHTR6 | |
| SCHEMBL2269949 | 0.78 | HTR2C (0.61) | SIGMAR1HTR2CQDPRHTR6CCNT1 | |
| Hydrochloric Acid SCHEMBL3690362 | 0.78 | HTR2C (0.61) | SIGMAR1HTR2CQDPRHTR6CCNT1 | |
| Hydrochloric Acid SCHEMBL29882300 | 0.78 | HTR2C (0.61) | SIGMAR1HTR2CQDPRHTR6CCNT1 | |
| SCHEMBL3961889 | 0.78 | SIGMAR1 (0.65) | SIGMAR1HTR2CQDPRKHKHTR6 | |
| Hydrochloric Acid SCHEMBL16422718 | 0.77 | HTR2C (0.58) | SIGMAR1HTR2CQDPRKHKHTR6 | |
| SCHEMBL6162919 | 0.77 | HTR2C (0.47) | SIGMAR1HTR2CQDPRKHKHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |