Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 9/20 | 0.51 |
| ▸ | QDPR | P09417 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269930 | 0.88 | SIGMAR1 (0.67) | SIGMAR1HTR2CQDPRHTR6 | |
| Hydrochloric Acid SCHEMBL16423171 | 0.87 | HTR2C (0.68) | SIGMAR1HTR2CQDPRHTR6 | |
| SCHEMBL4670817 | 0.82 | SIGMAR1 (0.57) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL6589127 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR2CQDPRHTR6MAPT | |
| SCHEMBL6584948 | 0.79 | SIGMAR1 (0.65) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL16434840 | 0.77 | HTR2C (0.57) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL6584726 | 0.76 | QDPR (0.46) | SIGMAR1HTR2CQDPRHTR6MAPT | |
| SCHEMBL6585457 | 0.76 | HTR2C (0.76) | SIGMAR1HTR2CQDPRSOS1 | |
| Hydrochloric Acid SCHEMBL16422718 | 0.76 | HTR2C (0.58) | SIGMAR1HTR2CQDPRHTR6HTR2A | |
| SCHEMBL6162919 | 0.75 | HTR2C (0.47) | SIGMAR1HTR2CQDPRHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |