Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7667728 | 0.89 | PPARG (0.49) | SIGMAR1PPARGPPARAHRH3PARP1 | |
| SCHEMBL6592540 | 0.84 | SIGMAR1 (0.58) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| SCHEMBL6587088 | 0.83 | SIGMAR1 (0.52) | SIGMAR1PPARGPPARAPARP1DRD2 | |
| Ssr-150106 SCHEMBL29393331 | 0.82 | SIGMAR1 (0.48) | SIGMAR1PPARGPPARAPARP1DRD2 | |
| SCHEMBL6586330 | 0.82 | HTR1A (0.52) | SIGMAR1HRH3PARP1DRD2DRD4 | |
| Ssr-150106 SCHEMBL1385047 | 0.82 | SIGMAR1 (0.48) | SIGMAR1PPARGPPARAPARP1DRD2 | |
| SCHEMBL27476786 | 0.81 | SIGMAR1 (0.39) | SIGMAR1HRH3PARP1SLC6A4DRD2 | |
| SCHEMBL6589537 | 0.78 | SIGMAR1 (0.51) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL4587751 | 0.78 | PPARG (0.51) | SIGMAR1PPARGPPARAPARP1DRD2 | |
| SCHEMBL4589104 | 0.78 | PPARG (0.51) | SIGMAR1PPARGPPARAPARP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B8 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |
| EP-1226137-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029026-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2001-04-26 | — | — | WO | disclosed |