Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6597378 | 0.95 | NPC1 (0.36) | NPC1RAB9AL3MBTL1CAMK2DPIM1 | |
| Trifluoroacetic Acid SCHEMBL6588085 | 0.91 | GSK3B (0.36) | CAMK2DPIM1HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6590147 | 0.88 | HSP90AA1 (0.38) | CAMK2DPIM1HSP90AA1PTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6585782 | 0.88 | CAMK2D (0.45) | CAMK2DPIM1HSP90AA1PTGDR2 | |
| SCHEMBL6590149 | 0.88 | CAMK2D (0.35) | CAMK2DPIM1HSP90AA1PTGDR2CNR1 | |
| Trifluoroacetic Acid SCHEMBL6590827 | 0.86 | PIM1 (0.35) | CAMK2DPIM1HSP90AA1KDM4ECYP1A2 | |
| Trifluoroacetic Acid SCHEMBL6586732 | 0.86 | PTGDR2 (0.37) | CAMK2DPIM1HSP90AA1KDM4EPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6591483 | 0.86 | GSK3B (0.37) | CAMK2DPIM1 | |
| Trifluoroacetic Acid SCHEMBL6588330 | 0.85 | CAMK2D (0.43) | CAMK2DPIM1HSP90AA1PTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6586373 | 0.85 | IDO1 (0.36) | CAMK2DPIM1HSP90AA1PTGDR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |