Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6591483 | 0.95 | GSK3B (0.37) | GSK3BQPCTPIM1CAMK2DPIK3R1 | |
| SCHEMBL6590149 | 0.91 | CAMK2D (0.35) | GSK3BPRKCAPIM1CAMK2DPLK1 | |
| Trifluoroacetic Acid SCHEMBL6590147 | 0.91 | HSP90AA1 (0.38) | GSK3BPIM1CAMK2DPLK1HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6589351 | 0.91 | NPC1 (0.36) | PIM1CAMK2DHSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6590827 | 0.90 | PIM1 (0.35) | GSK3BPIM1CAMK2DPLK1HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6588255 | 0.90 | CAMK2D (0.43) | GSK3BPRKCAPIM1CAMK2D | |
| Trifluoroacetic Acid SCHEMBL6586732 | 0.90 | PTGDR2 (0.37) | GSK3BPIM1CAMK2DPLK1HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6585782 | 0.89 | CAMK2D (0.45) | PIM1CAMK2DHSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6586373 | 0.89 | IDO1 (0.36) | GSK3BPRKCAPIM1CAMK2DPLK1 | |
| SCHEMBL6589392 | 0.89 | GSK3B (0.41) | GSK3BQPCTPIM1CAMK2DPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |