Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6590085 | 0.94 | HSP90AA1 (0.38) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6590827 | 0.92 | PIM1 (0.35) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6586732 | 0.92 | PTGDR2 (0.37) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6585782 | 0.91 | CAMK2D (0.45) | HSP90AA1PIM1CAMK2DPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6586373 | 0.91 | IDO1 (0.36) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6588085 | 0.91 | GSK3B (0.36) | HSP90AA1PIM1CAMK2DGSK3BPLK1 | |
| Trifluoroacetic Acid SCHEMBL6591980 | 0.90 | ICMT (0.37) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6589143 | 0.90 | PIM1 (0.33) | HSP90AA1PIM1CAMK2DPTGDR2PLK1 | |
| Trifluoroacetic Acid SCHEMBL6586877 | 0.89 | ICMT (0.38) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 | |
| SCHEMBL6590149 | 0.89 | CAMK2D (0.35) | HSP90AA1PIM1CAMK2DGSK3BPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |