SCHEMBL6589438

SCHEMBL6589438

O=[C]Nc1cccnc1Br

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.42
TRIM33 Q9UPN9 1/20 0.42
TDP1 Q9NUW8 4/20 0.33
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
AXL P30530 1/20 0.32
CDC25B P30305 1/20 0.32
MAPK10 P53779 1/20 0.32
GFER P55789 1/20 0.32
RAB9A P51151 2/20 0.32
HTT P42858 2/20 0.32
ALOX15 P16050 1/20 0.32
GLO1 Q04760 1/20 0.32
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
NFKBIA P25963 1/20 0.31
RELA Q04206 1/20 0.31
SLC40A1 Q9NP59 1/20 0.31
HDAC6 Q9UBN7 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27950829 0.76 NAPRT (0.41) MEN1KMT2AMAPK10GFERRAB9A
SCHEMBL27935605 0.76 SMN1; SMN2 (0.49) TDP1MEN1KMT2ARAB9AHTT
SCHEMBL7394738 0.76 P2RX7 (0.41) TDP1MEN1KMT2AHTTALOX15
SCHEMBL3425372 0.73 GLO1 (0.56) TDP1MEN1KMT2AHTTALOX15
SCHEMBL5198177 0.72
SCHEMBL6589447 0.72 TRIM24 (0.52) TRIM24TRIM33TDP1MEN1KMT2A
SCHEMBL349575 0.72 MEN1 (0.57) TDP1MEN1KMT2AHTTALOX15
SCHEMBL5636859 0.72 SLC22A12 (0.45) TDP1MEN1KMT2AGFERRAB9A
SCHEMBL1446148 0.71 TDP1 (0.42) TRIM24TRIM33TDP1MEN1KMT2A
SCHEMBL11463688 0.70 L3MBTL1 (0.37) TDP1RAB9AHTTALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019378-B1 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS LILLY CO ELI (US) 2004-09-29 EP disclosed
US-6541497-B1 Amino acid derivatives of benzoxazin-2-ylaminoalkoxyphenylalkyl compounds ELI LILLY AND COMPANY 2003-04-01 US disclosed
US-6353027-B1 ENANTIOMORPHIC AMINE DERIVATIVES FOR TREATMENT OF DIABETES ELI LILLY AND COMPANY 2002-03-05 US disclosed
EP-1019378-A4 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS LILLY CO ELI (US) 2001-09-26 EP disclosed
US-6194446-B1 NON-INSULIN DEPENDENT DIABETES ELI LILLY AND COMPANY 2001-02-27 US disclosed
EP-0925063-A4 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS LILLY CO ELI (US) 2000-12-27 EP disclosed
US-6121282-A 3-(CARBOXY, AMIDO, CYANO, OR HYDROXYAMINOCARBONYL)-6 OR 7-SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE COMPOUNDS ELI LILLY AND COMPANY (US) 2000-09-19 US disclosed
EP-1019378-A1 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS ELI LILLY AND COMPANY (US) 2000-07-19 EP disclosed
EP-0925063-A1 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS ELI LILLY AND COMPANY (US) 1999-06-30 EP disclosed
WO-1998000137-A1 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS ELI LILLY AND COMPANY (US) 1998-01-08 WO disclosed
WO-1998000403-A1 HYPOGLYCEMIC AND HYPOLIPIDEMIC COMPOUNDS ELI LILLY AND COMPANY (US) 1998-01-08 WO disclosed