Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.61 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588599 | 0.86 | NPC1 (0.55) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL6587830 | 0.83 | MEN1 (0.47) | P2RY14GLSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6587745 | 0.82 | KMT2A (0.56) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL6589440 | 0.82 | NLRP3 (0.58) | NLRP3P2RY14EPHX2CCNA2CDK2 | |
| SCHEMBL6587226 | 0.81 | USP2 (0.56) | P2RY14CCNA2CDK2CCNA1GLS | |
| SCHEMBL6586518 | 0.80 | RAB9A (0.47) | GLSSMN1; SMN2LMNA | |
| SCHEMBL2954162 | 0.78 | ALDH1A1 (0.59) | NLRP3P2RY14EPHX2CCNA2CDK2 | |
| SCHEMBL6590589 | 0.77 | ALDH1A1 (0.40) | MEN1KMT2AHTT | |
| SCHEMBL6588758 | 0.76 | SMN1; SMN2 (0.58) | P2RY14GLSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6585363 | 0.74 | NPC1 (0.59) | CDK2SMN1; SMN2MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |